Complex Formulation Systems
Engineering advanced delivery systems to enable predictable, clinically relevant exposure for molecules limited by solubility, stability, or permeability.
Where We Deliver Impact
Improving Oral Exposure
Enabling clinically viable bioavailability for poorly soluble molecules through lipid-based and enabling formulations
Bridging Preclinical to Clinical
Aligning formulation strategy with PK modelling and human exposure targets to reduce first-in-human uncertainty
Rescuing Stalled Assets
Reviving molecules limited by variability, instability, or inconsistent performance
Our Approach
Solubility Enhancement & Absorption Strategies
Designing systems to improve dissolution and absorption using lipid platforms, enabling formulations, and permeability enhancement strategies
Solid-State & Dispersion Engineering
Optimising physical form and molecular presentation to improve stability, manufacturability, and in vivo performance consistency
Lipid-Based & Advanced Carrier Systems
Leveraging lipid platforms and delivery carriers to enhance systemic exposure, reduce variability, and enable lymphatic uptake where relevant
Formulation–Performance Alignment
Linking formulation design to expected in vivo behaviour through integration with PK modelling and biopharmaceutic principles
Outcomes
- Achieved predictable and reproducible systemic exposure
- Reduced inter- and intra-subject variability in absorption profiles
- Enabled progression of previously non-viable molecules into clinical evaluation
- Improved formulation robustness and manufacturability
- Aligned early development decisions with clinical exposure targets
Where this fits in development
Applied during early and mid-stage development to design formulations that enable clinically meaningful exposure, reduce first-in-human risk, and support efficient progression into clinical studies.
Ready to translate molecular potential into clinical performance?
Partner with Dhee Lifesciences to design formulation strategies that deliver predictable exposure, reduced development risk, and faster clinical progression.
